pregnancies following the use of sequential treatment of metformin and incremental doses of letrozole in clomiphen-resistant women with polycystic ovary syndrome
نویسندگان
چکیده
background: clomiphen citrate (cc) is the first line therapy for women with infertility and poly cystic ovary syndrome( pcos). however, 20-25% of women are resistant to cc and do not ovulate. objective: the objective of this study was to evaluate the efficacy of sequential treatment of metformin and incremental doses of letrozole in induction of ovulation in cases of cc-resistant pcos patients. materials and methods: in this prospective before-after study, we enrolled 106 anovulatory pcos women who failed to ovulate with cc alone from amir-almomenin university hospital in semnan, iran. after an initial 6-8 weeks of metformin treatment, they received 2.5 mg letrozole daily on days 3-7 after menes. if they did not ovulate with 2.5 mg letrozole, the doses were increased to 5 to 7.5 mg daily in subsequent cycles. the main outcomes were ovulatory rate, pregnancy rate and cumulative pregnancy rate. results: 13.33% of patients conceived with metformin alone. ovulation occurred in 83 out of remaining 91 patients (91.2%). 78.02% of patients responded to lower doses of letrozole. cumulative pregnancy rate was 60/ 105 (57.14%). conclusion: we suggest that treatment in cc-resistant pcos patients should begin at first with lower doses of letrozole and could increase to the higher dose depending on the patient response before considering more aggressive therapeutic alternatives such as gonadotropins.
منابع مشابه
Pregnancies following the use of sequential treatment of metformin and incremental doses of letrozole in clomiphen-resistant women with polycystic ovary syndrome
BACKGROUND Clomiphen citrate (CC) is the first line therapy for women with infertility and poly cystic ovary syndrome( PCOS). However, 20-25% of women are resistant to CC and do not ovulate. OBJECTIVE The objective of this study was to evaluate the efficacy of sequential treatment of metformin and incremental doses of letrozole in induction of ovulation in cases of CC-resistant PCOS patients....
متن کاملO-29: Pregnancies Following the Use of SequentialTreatment of Metformin and IncrementalDoses of Letrozole in Clomiphen-ResistantWomen with Polycystic Ovary Syndrome
Background: Clomiphen citrate (CC) is the first line therapy for women with infertility and poly cystic ovary syndrome( PCOS).However, 20-25% of women are resistant to CC and do not ovulate. The Background of this study is to evaluate the efficacy of sequential treatment of metformin and incremental doses of letrozole in induction of ovulation in cases of clomiphen citrateresistant (CC- R) PCOS...
متن کاملComparison of Letrozole Versus Tamoxifen Effects in Clomiphen Citrate Resistant Women with Polycystic Ovarian Syndrome
BACKGROUND The objective of this prospective randomized study was to make a comparison between the effects of letrozole and tamoxifen (TMX) in ovulation induction in clomiphene (CC)-resistant women with polycystic ovarian syndrome (PCOS). METHODS The study comprised a total of 60 infertile women (180 cycles) with CCresistant PCOS selected from the clinics affiliated to the Department of Obste...
متن کاملUse of metformin for women with polycystic ovary syndrome.
Polycystic ovary syndrome (PCOS) affects up to 15% of women of reproductive age and is characterized by hyperandrogenism, menstrual disturbance, anovulatory infertility and obesity. A large body of evidence has indicated that increased insulin resistance and compensatory hyperinsulinaemia play a key role in the pathogenesis of PCOS. At least 40% of women with PCOS are obese and are more insulin...
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چکیده ندارد.
15 صفحه اولcomparison of letrozole versus tamoxifen effects in clomiphen citrate resistant women with polycystic ovarian syndrome
background: the objective of this prospective randomized study was to make a comparison between the effects of letrozole and tamoxifen (tmx) in ovulation induction in clomiphene (cc)-resistant women with polycystic ovarian syndrome (pcos). methods: the study comprised a total of 60 infertile women (180 cycles) with cc-resistant pcos selected from the clinics affiliated to the department of obst...
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عنوان ژورنال:
international journal of reproductive biomedicineجلد ۱۰، شماره ۱، صفحات ۳۳-۰
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